Calcification and Expression of Bone Morphogenetic Protein-4 in Papillary Thyroid Carcinoma

Background/Aim: The purpose of this study was to investigate whether bone morphogenetic protein (BMP)-4 expression differs according the presence calcification in papillary thyroid carcinoma and if BMP-4 are associated with metastasis carcinoma.Methods: We performed using paraffin-embedded tissues 55 patients who underwent thyroidectomy Kosin University Gospel Hospital. Of those cases, 36 were carcinomas, 19 benign tumors. Immunohistochemical staining BMP4 antibody on tissues.Results: Among 20 (55.6%) extrathyroidal invasion 21 (58.3%) lymph node observed. significantly different incidence extranodal (p = 0.02), lymphovascular < 0.001), 0.04). weakly positive tumors strongly 0.001). by TNM stage 0.001).Conclusion: In present study, tumor metastasis. expressed carcinoma.